Figure 1.

HIT in C57BL/6J, A/J, and 19 chromosome substitution strains. The time (latency) required for a mouse to make a coordinated movement after it is placed on a vertical mesh screen before (day 0) and after treatment with haloperidol (3 mg⋅kg⁻¹⋅day⁻¹ via continuous release from an implanted pellet) for 5 or 10 days is shown. Each bar represents the average ± SEM for three to four mice per strain. Only CSS12 and CSS10 mice (which have A/J alleles for every gene on chromosome 12 or 10, respectively, on an otherwise C57BL/6 background) had significantly increased latencies after both 5 and 10 days of haloperidol treatment. No other CSS mice exhibited a significant increase in latency after treatment day 5; and the small increases in the measured latencies of CSS2 and CSS14 mice after 10 days of haloperidol treatment were not significant (P > 0.05) after correction for the multiple comparisons.