Figure 6.

Cystamine administration reduces the infarct volume after ischemic injury in A/J, CSS10, and C57BL/6J mice. Male A/J, CSS10, and C57BL/6J mice were treated with cystamine (10 mg⋅kg⁻¹⋅day⁻¹ ip) (n = 5, 4, and 8 mice per group, respectively) or saline (n = 8, 4, and 7 mice per group, respectively) for 5 days. Then, 24 hr after MCA occlusion, whole brains were obtained to assess the infarct size. Each bar represents the average (± SEM) of the infarct size. The infarct size in the control group was significantly reduced by cystamine administration in A/J mice (56.8% vs. 44.0%, P = 0.01), CSS10 mice (50.1% vs. 27.5%, P = 0.02) and C57BL/6J mice (25.4% vs. 16.4%, P = 0.028).