Table 1.

McNemar’s χ² test of haplotype proportions from pre- and post-treatment parasite pairs

	Pre- and post-treatment
	Pre	Post		McNemar’s χ2 (p value)	OR (95 % CI)
AMA1		DQRHFDKY	Other
	DQRHFDKY	0	0
	Other	2	8	2 (0.16)	ND
EBA140		VSTK	Other
	VSTK	5	2
	Other	3	5	0.2 (0.65)	0.9 (0.5–1.6)
EBA181		Q	K
	Q	5	4
	K	2	2	0.67 (0.41)	1.3 (0.7–2.4)
EBA175		EKEKPISENKKK	Other
	EKEKPISENKKK
	Other	No data
EBL-1		QFFFF.VN	Other
	QFFFF.VN
	Other	No data
MSP1		KD	Other
	KD	7	2
	Other	5	3	1.29 (0.26)	0.8 (0.5–1.2)
MSP3		K1	3D7
	K1	4	2
	3D7	3	0	0.2 (0.65)	0.9 (0.4–1.7)
MSP6		K1	3D7
	K1	1	2
	3D7	3	9	0.2 (0.65)	0.8 (0.2–2.7)
MSPDBL1		ALTAIKY	Other
	ALTAIKY
	Other	No data
MSPDBL2		AHQAIRY	Other
	AHQAIRY	2	6
	Other	7	3	0.08 (0.78)	0.9 (0.4–2.0)
Rh1		4HN2QN	Other
	4HN2QN	1	2
	Other	1	3	0.33 (0.56)	1.5 (0.4–6.0)
Rh2b		156insQ585del	Other
	156insQ585del
	Other	No data
Rh5		HD	YH
	HD	13	4
	YH	0	3	4 (0.046)	1.3 (1.0–1.7)

italic value indicates a significant increase in the odds of the Rh5 haplotypes changing compared to staying the same between parasite pairs before and after treatment

Other represents genes with more than 2 high frequency haplotypes, the dominant allele was compared to all other alleles in the population, ND not determined, No data insufficient pairs for the analysis <4