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. 2016 May 6;17:94. doi: 10.1186/s13059-016-0952-x

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© Pandolfini et al. 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 3 — a GO terms significantly enriched in both gene sets of mRNAs released from Ago (Ago-RIP, gray) and of mRNAs significantly loaded on ribosomes (Polysome profiling, dark blue) at the ES–ELA transition, as obtained by DAVID (see “Methods”). Fold enrichment bars are grouped according to DNA replication, chromatin regulation, and embryonic development terms; a complete list of all enriched terms in each subset is provided in Additional file 3: Table S2. b Distribution of log₂ ribosome enrichment variation (RiboΔE) during the ES–ELA transition. c, d Box plots of Ago enrichment (c) and log₂ ribosome enrichment (Ribo Enrichment) (d) of mRNAs belonging to distinct classes of chromatin regulators, as listed in Histome [25] (for a complete list of genes taken into account see also Additional file 3: Table S2). In red, families showing statistically significant differences in enrichment. HAT histone acetyl-transferases, HDAC histone deacetylases, HMT histone methyl-transferases, PRC1/2 Polycomb repressor complex 1/2. *p = 0.05, **p = 0.01, ***p = 0.001 (Wilcoxon test)