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. 2016 May 5;17:205. doi: 10.1186/s12891-016-1055-2

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© Suzuki et al. 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 4 — Cytokine response in wild-type and Padi4^−/− mice after collagen-induced arthritis (CIA) treatment. Wild-type (n = 30) and Padi4^−/− (n = 24) mice were challenged with CIA, and serum cytokine protein levels were determined by ELISA on day 28. a tumor necrosis factor alpha (TNF-α), b interleukin (IL)-1β, c Granulocyte-macrophage colony-stimulating factor (GM-CSF), d IL-6. * P < 0.01, **P < 0.001 (Student’s t-test)