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. 2016 May 5;17:205. doi: 10.1186/s12891-016-1055-2

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© Suzuki et al. 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 6 — Immunohistochemical localization of antigens detected by anti-CCP antibodies in synovial tissues. Immunohistochemistry with anti-circulated citrullinated peptide (anti-CCP) antibody (Abbiotec), brown staining of the lining and sublining in the inflamed synovial tissue from wild-type collagen-induced arthritis (CIA) mice (f and g) and Padi4^−/− CIA mice (b and c) and in the synovial tissue from wild-type control mice (e) and Padi4^−/− control mice (a). Staining of a matched irrelevant rabbit IgG-negative control was performed at the same concentration (d and h). In OA (i) and RA synovial tissue samples (j), CCP antigens were observed in the synovial sublining and lining layer. Magnification is × 40, except in c, g and j lower (×100)