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. 2016 Jan 27;15(5):1498–1510. doi: 10.1074/mcp.M115.055772

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© 2016 by The American Society for Biochemistry and Molecular Biology, Inc.

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Fig. 7. — HuR and QKI-5 proteins are deregulated in MTAP± mice as in SK-Hep1 cells. (A) Western blotting analysis revealed a threefold increase of HuR in MTAP± liver mice. (B) HuR activation by accumulation of MTA was further confirmed in WT and MTAP-deficient hepatocytes upon HGF stimulation. Furthermore, PCNA and cyclin A, HuR targets, were up-regulated. (C) QKI steady-state levels were similar in WT and MTAP± livers. (D) R-methyl-protein-IP combined with WB analysis revealed QKI-5 hypermethylation, providing support to our findings in SK-Hep1+ cells containing normal MTA levels.