FIGURE 7.

Details of p58_C interaction with a template/primer. A, electron density map for the DNA/RNA duplex and the triphosphate coordinating Mg²⁺. The carbons of DNA and RNA are colored green and gray, respectively. B, F_o − F_c Fourier map (contour level at 5σ) for Mn²⁺ coordinated by a 5′-triphosphate of RNA. C, alignment of p58_C from different structures points to the flexibility of the DNA-interacting loop 354–366. The PDB accession numbers for the structures of the human primase and p58_C are 4RR2 and 3Q36, respectively.