FIGURE 2.

18% CS augmented EC permeability and adherens junction disassembly caused by low dose of thrombin. HPAEC were subjected to 18% CS for 120 min or left under static (ST) conditions, followed by thrombin stimulation (0.1 unit/ml) for the last 15 min of the experiment. A, permeability measurements were performed using FITC-avidin fluorescence XPerT assay. n = 4; *, p < 0.05 versus static conditions. AU, arbitrary units. B, adherens junction remodeling was assessed by immunofluorescence staining for VE-cadherin. The results are representative of three independent experiments (relative density units).