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Amino acid sequences of the CDR regions for mAbs S1–15, A6, S55–3, and S55–5
Numbering is based on the Kabat scheme. The sequence of S1–15 originates from germ line 1 (GL-1) sequences. A6 H-chain belongs to the GL-2 sequence and the L-chain to GL-1. MAbs S55–3 and S55–5 both belong to GL-3 sequences. Underlined amino acids are mutated from the germ line and residues in bold are contacting the lipid A antigen directly or through water bridges.
