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Long lasting effect of Hsp90 inhibition. A, PBMC pretreated with 1 μm 17-AAG for 24 h were inoculated with HIV at multiplicity of infection of 0.001 and 0.1 from 1 to 6 days after drug treatment. Supernatant p24 was estimated after 7 days of culture. B, uninfected PBMC pretreated with 1 μm 17-AAG for 24 h were tested for cytotoxicity from 1 to 6 days after drug treatment. Data represent mean ± S.E. (error bars) (n = 4).
