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Effect of kindlin-3 knockdown on the cell resistance to detachment. A and B, resistance of K562-α4β1 control cells and transfectants to detachment at increasing wall shear stress in 1 mm Ca2+/Mg2+ (A) or 1 mm Mn2+ (B). The total number of cells remaining bound at each indicated wall shear stress was determined as a percentage of adherent cells at 1 dyne/cm2. Error bars represent ±S.D. (n = 3).
