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. 2016 Apr 18;5(4):e002663. doi: 10.1161/JAHA.115.002663

Figure 1.

Figure 1

A, Study design. Blue lines represent time periods in which mice were fed regular chow; periods of WD feeding are represented in orange. Red arrows indicate times of blood sampling. B, Time course of plasma cholesterol elevation after introduction of WD. Mice were not fasted for these plasma measurements (n=5). C, D, and E, Fasting plasma cholesterol (C), triglyceride (D), and oxLDL (E) levels at time of death in mice used for gene expression studies (n=5). F, Cholesterol distribution in different lipoprotein fractions in pooled plasmas obtained at week 22 under overnight fasting. *P<0.005 and **P<0.001 with respect to CHOW; # P<0.05 with respect to 2‐week WD. HDL indicates high‐density lipoprotein; IDL, intermediate‐density lipoprotein; LDL, low‐density lipoprotein; oxLDL, oxidized low‐density lipoprotein; VLDL, very low‐density lipoprotein; WD, Western‐type diet.