Table 2.
Multivariable Models for Renal Outcomes
| Variable | ESRD | ESRD or Death | ||
|---|---|---|---|---|
| HR (95% CI) | P Value | HR (95% CI) | P Value | |
| Known CAD | 1.20 (1.01–1.42) | 0.041 | 1.15 (1.01–1.30) | 0.031 |
| Age | 1.00 (0.99–1.00) | 0.432 | 1.02 (1.01–1.02) | <0.001 |
| Male sex | 1.69 (1.44–1.99) | <0.001 | 1.42 (1.26–1.59) | <0.001 |
| Race (referent: white) | ||||
| Black | 1.72 (1.43–2.08) | <0.001 | 1.27 (1.10–1.47) | 0.001 |
| Other | 1.00 (0.81–1.25) | 0.966 | 0.92 (0.77–1.08) | 0.312 |
| BMI, per 10 kg/m2 | 0.81 (0.71–0.92) | 0.001 | 0.80 (0.74–0.88) | <0.001 |
| Insulin use | 1.15 (0.97–1.36) | 0.112 | 1.14 (1.00–1.29) | 0.042 |
| eGFR, per 10 mL/min/1.73 m2 | 0.52 (0.47–0.58) | <0.001 | 0.77 (0.71–0.82) | <0.001 |
| BUN, per 10 mg/dL | 1.12 (1.06–1.17) | <0.001 | 1.08 (1.04–1.13) | <0.001 |
| Log (UPCR) | 1.87 (1.73–2.02) | <0.001 | 1.42 (1.35–1.49) | <0.001 |
| Albumin, per 1 g/dL | 0.70 (0.58–0.84) | <0.001 | 0.61 (0.53–0.70) | <0.001 |
| Prior stroke | 1.17 (0.91–1.50) | 0.211 | 1.30 (1.11–1.53) | 0.002 |
| Prior PAD | 1.10 (0.90–1.35) | 0.355 | 1.13 (0.98–1.30) | 0.084 |
| Prior HF | 1.30 (1.09–1.56) | 0.004 | 1.49 (1.31–1.69) | <0.001 |
| History of arrhythmia | 1.17 (0.93–1.48) | 0.189 | 1.27 (1.09–1.48) | 0.002 |
| Hemoglobin, per 1 g/dL | 0.95 (0.88–1.03) | 0.188 | 0.95 (0.90–1.00) | 0.073 |
| Log (ferritin) | 1.10 (1.01–1.19) | 0.030 | 1.04 (0.98–1.11) | 0.202 |
| CRP (referent: ≤3.0 mg/L) | ||||
| CRP 3.1–6.5 mg/L | 1.13 (0.93–1.37) | 0.229 | 1.16 (1.00–1.34) | 0.044 |
| CRP ≥6.6 mg/L | 1.31 (1.08–1.58) | 0.006 | 1.42 (1.24–1.63) | <0.001 |
| History of acute kidney injury | 1.32 (1.05–1.66) | 0.019 | 1.22 (1.03–1.45) | 0.023 |
| Systolic blood pressure | 1.00 (1.00–1.01) | 0.248 | 1.00 (1.00–1.00) | 0.763 |
| Duration of T2DM | 1.00 (1.00–1.00) | 0.109 | 1.00 (1.00–1.00) | 0.835 |
| Treatment with darbepoetin | 1.08 (0.93–1.26) | 0.321 | 1.12 (1.00–1.25) | 0.044 |
BMI indicates body mass index; BUN, blood urea nitrogen; CAD, coronary artery disease; CRP, C‐reactive protein; eGFR, estimated glomerular filtration rate; ESRD, end‐stage renal disease; HF, heart failure; HR, hazard ratio; PAD, peripheral artery disease; T2DM, type 2 diabetes mellitus; UPCR, urine protein/creatinine ratio.