. 2016 Apr 3;5(4):e002930. doi: 10.1161/JAHA.115.002930

Table 4.

Effects of Baseline AHI Severity and PAP Use on Cardiovascular Outcomes—Main Effects Models

Outcome Changes	Baseline Log₁₀(AHI+1)		PAP Use (Hours/Night)
Outcome Changes	Beta (SE)	P Value	Beta (SE)	P Value
Brachial systolic BP, mm Hg	−3.80 (3.15)	0.230	0.66 (0.46)	0.150
Diastolic BP, mm Hg	−3.61 (2.23)	0.107	−0.65 (0.32)^a	0.045^a
Mean pressure, mm Hg	−3.00 (1.99)	0.134	−0.36 (0.29)	0.214
Central systolic BP, mm Hg	−4.00 (2.53)	0.115	0.10 (0.37)	0.782
Body mass index, kg/m²	0.68 (0.28)^a	0.017^a	0.03 (0.04)	0.399
Brachial artery diameter, mm	0.17 (0.06)^a	0.008^a	0.01 (0.01)	0.326
Maximum relative FMD (%)	−1.41 (0.97)	0.150	0.34 (0.14)^a	0.015^a
Maximum absolute FMD, mm	−0.07 (0.04)	0.085	0.02 (0.01)^a	0.007^a
HR‐corrected augmentation index (%)	−3.25 (1.87)	0.084	−0.53 (0.27)^a	0.049^a
PWV_c‐f (femoral), m/sec	−0.23 (0.31)	0.460	−0.01 (0.04)	0.860
PWV_c‐r (carotid), m/sec	−0.90 (0.32)^a	0.006^a	−0.13 (0.05)^a	0.007^a
LV ejection fraction (%)	3.03 (1.41)^a	0.034^a	−0.04 (0.20)	0.845
PA systolic pressure, mm Hg	5.45 (1.88)^a	0.004^a	−0.05 (0.27)	0.847
Cardiac output, L/min	0.81 (0.29)^a	0.006^a	0.00 (0.04)	0.913
SVR (SD)	−0.79 (0.24)^a	0.001^a	−0.01 (0.03)	0.690
Diastolic function (grade)	−1.03 (0.31)^a	0.001^a	0.10 (0.05)^a	0.028^a

Both predictor variables included simultaneously in the models. Output reflects repeated measures modeling. Models adjusted for age, sex, BMI, baseline SBP, and baseline BP medications. FMD models included brachial artery diameter as a covariate. Indexed measures did not include AHI indicates apnea hypopnea index; BMI as a covariate. BMI, body mass index; BP, blood pressure; FMD, flow‐mediated vasodilation; LV, left ventricle; PAP, positive airway pressure; PWV_c‐f, carotid‐femoral pulse wave velocity; PWV_c‐r, carotid‐radial pulse wave velocity; SE, standard error; SVR, systemic vascular resistance.

P<0.05.