Table 4.
Proportional Hazards Model Results for the ICE‐PCS Derivation (n=2646) and ICE‐PLUS Validation (n=887) Cohorts and 6‐Month Mortality
| Variable | ICE‐PCS | ICE‐PLUS | ||
|---|---|---|---|---|
| HR (95% CI) | P Value | HR (95% CI) | P Value | |
| Age 46–60 y | 1.51 (1.29–1.78) | <0.0001 | 1.69 (1.28–2.25) | 0.0003 |
| Age 61–70 y | 1.87 (1.58–2.20) | <0.0001 | 1.79 (1.34–2.40) | <0.0001 |
| Age >70 y | 2.90 (2.50–3.37) | <0.0001 | 3.09 (2.40–4.01) | <0.0001 |
| History of dialysis | 2.04 (1.80–2.31) | <0.0001 | 2.08 (1.56–2.73) | <0.0001 |
| Nosocomial IE | 1.47 (1.33–1.63) | <0.0001 | 1.48 (1.23–1.77) | <0.0001 |
| Prosthetic IE | 1.20 (1.09–1.32) | 0.0002 | 1.09 (0.92–1.30) | 0.33 |
| IE symptom onset to admission >30 days | 0.74 (0.65–0.84) | <0.0001 | 1.08 (0.90–1.29) | 0.42 |
| Staphylococcus aureus IE | 1.42 (1.29–1.56) | <0.0001 | 1.55 (1.30–1.86) | <0.0001 |
| Viridans group IE | 0.63 (0.53–0.75) | <0.0001 | 0.80 (0.62–1.02) | 0.08 |
| Aortic vegetation | 1.21 (1.09–1.33) | 0.0002 | 1.21 (1.03–1.42) | 0.02 |
| Mitral vegetation | 1.20 (1.08–1.32) | 0.0004 | 0.99 (0.92–1.02) | 0.63 |
| NYHA class 3 or 4 | 2.19 (2.00–2.39) | <0.0001 | 1.60 (1.20–2.10) | 0.0009 |
| Stroke | 1.76 (1.60–1.94) | <0.0001 | 1.65 (1.39–1.94) | <0.0001 |
| Paravalvular complication | 1.47 (1.34–1.61) | <0.0001 | 1.32 (1.13–1.54) | 0.0005 |
| Persistent bacteremia | 1.53 (1.35–1.72) | <0.0001 | 1.92 (1.56–2.35) | <0.0001 |
| Surgical treatment | 0.66 (0.60–0.74) | <0.0001 | 0.74 (0.62–0.89) | 0.0012 |
| Harrell's C statistic | 0.715 | 0.682 | ||
HR indicates hazard ratio; ICE, International Collaboration on Endocarditis; IE, infective endocarditis; NYHA, New York Heart Association; PCS, Prospective Cohort Study.