Table 6.
Comparison of Clinical Characteristics of IE in the International Collaboration on Endocarditis–PLUS Cohort by Quintiles of Risk for 6‐Month Mortality
| Variable | Quintile of Risk for 6‐Month Mortality | P Value | ||||
|---|---|---|---|---|---|---|
| 1 (n=224) | 2 (n=188) | 3 (n=200) | 4 (n=98) | 5 (n=172) | ||
| Host factors | ||||||
| Age ≤45 y | 58.9 | 16.5 | 11.0 | 6.1 | 1.7 | <0.001 |
| Age 46–60 y | 23.7 | 33.5 | 19.5 | 19.4 | 9.9 | |
| Age 61–70 y | 12.1 | 23.4 | 18.5 | 30.6 | 26.2 | |
| Age >70 y | 5.4 | 26.6 | 51.0 | 43.9 | 62.2 | |
| History of dialysis | 0.4 | 2.1 | 1.5 | 7.1 | 16.3 | <0.001 |
| History of diabetes | 7.1 | 14.9 | 23.0 | 27.6 | 36.0 | <0.001 |
| IE factors | ||||||
| Nosocomial IE | 0.9 | 7.4 | 14.0 | 28.6 | 44.8 | <0.001 |
| Prosthetic IE | 14.3 | 25 | 33.0 | 35.7 | 41.3 | <0.001 |
| Staphylococcus aureus | 12.1 | 18.6 | 19.0 | 24.5 | 42.4 | <0.001 |
| Viridans group streptococci | 36.2 | 19.1 | 12.0 | 6.1 | 1.2 | <0.001 |
| Aortic vegetation | 33.0 | 44.1 | 43.0 | 37.8 | 46.5 | 0.048 |
| Mitral vegetation | 42.9 | 42 | 53.5 | 52.0 | 53.5 | 0.067 |
| IE complications | ||||||
| NYHA class 3 or 4 | 0.0 | 2.7 | 4.5 | 10.2 | 14.5 | <0.001 |
| Stroke | 9.4 | 14.4 | 20.0 | 28.6 | 41.3 | <0.001 |
| Paravalvular complication | 17.0 | 27.7 | 42.0 | 42.9 | 50.6 | <0.001 |
| Persistent bacteremia | 4.0 | 4.8 | 8.0 | 17.3 | 26.7 | <0.001 |
| Surgical treatment | 79.9 | 67.6 | 47.0 | 35.7 | 25.0 | <0.001 |
| 6‐month mortality | 10.3 | 17.0 | 25.5 | 37.8 | 52.9 | <0.001 |
IE indicates infective endocarditis; NYHA, New York Heart Association.