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editorial

. 2016 Apr 23;5(4):e003596. doi: 10.1161/JAHA.116.003596

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© 2016 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley Blackwell.

This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.

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Microvascular and macrovascular diseases in patients with diabetes lead to loss of kidney function through proteinuric and nonproteinuric kidney disease. There is a bidirectional relationship between loss of glomerular filtration rate and progression of atherosclerosis. In addition to CKD‐specific risk factors, these patients have an increased burden of traditional and novel risk factors for CVD, which accelerates the progression of atherosclerosis. The association between coronary artery disease and progression of CKD could be related to acute KI (due to exposure to radiocontrast and coronary artery bypass surgery) and heart failure. CKD indicates chronic kidney disease; CVD, cardiovascular disease; GFR, glomerular filtration rate; KI, kidney injury.