Table 1.

Summary of effective iPSC-derived cell therapies for demyelinated models

Transplanted cells	Intermediate cells	Original cells	Demyelinated models	Conclusions	Refs
OPCs	iPSC	Mouse embryonic fibroblast	Cuprizone-induced model	Developed into mature OLs and contributed to remyelination	[53]
OPCs	iPSC	Human dermal fibroblast	Lysolecithin-induced model	Improved remyelination of the optic chiasm, as well as nerve function	[54]
OPCs	iPSC	Human fibroblast, Human keratinocyte	Congenital hypomyelination model	Formed myelin in the brains of shiverer mice and increased their survival	[22]
OPCs	iPSC	Fibroblast of PPMS patient	Congenital hypomyelination model	Differentiated to OLs in vitro and successfully ensheathed axons in vivo	[20]
NSCs	iPSC	Mouse embryonic fibroblast	MOG-induced EAE	Restrained demyelination, promoted remyelination; Trophic effect limited CNS-confined inflammation	[21]
iNSCs	iNSCs	Mouse embryonic fibroblast	Congenital hypomyelination model	Generated MBP+ myelin sheets in white-matter tracts of the cerebellum	[65]
iOPCs	iOPC	Mouse embryonic fibroblast	Congenital hypomyelination model	Generated compact myelin in vitro and in vivo	[66]
iOPCs	iOPC	Rat fibroblast	Congenital hypomyelination model	Differentiated into myelinating OLs and formed myelin in vivo	[67]