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. 2016 May 6;7:82. doi: 10.3389/fgene.2016.00082

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Copyright © 2016 Czapiewski, Robson and Schirmer.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Nut-and-bolt model for anchoring tethers. Nesprins (KASH-domain NETs) in the ONM connect in the lumen just under the membrane to SUN protein NETs in a trimeric interface stabilized by a triple helix formed by the three SUN protein molecules. This fanning out under the membrane could better distribute forces to withstand pulling forces from cytoplasmic filaments. NE-genome anchoring tethers could similarly utilize interactions with other NETs and luminal proteins to distribute chromosomal forces and prevent the NETs from being pulled from the membrane.