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Hypertension is the steadfast underpinning of heart failure with preserved ejection (HFpEF). Aging, obesity, pulmonary hypertension (PH), and coronary artery disease (CAD) affect HFpEF presentation and progression. Their presence defines 4 common phenotypes that share atrial fibrillation, anemia, chronic obstructive pulmonary disease (COPD), frailty, diabetes, obstructive sleep apnea, and chronic kidney disease (CKD) as comorbid conditions. HTN indicates hypertension.
