Table 1.
Variable | WT Saline (n=10) | WT Dox (n=10) | ITCH‐Tg Saline (n=10) | ITCH‐Tg Dox (n=10) |
---|---|---|---|---|
BW before, g | 23.6±1.5 | 23.2±1.4 | 23.6±2.1 | 23.9±1.5 |
BW after, g | 23.7±1.6 | 19.4±2.5a | 23.9±2.1b | 20.9±1.9a, b, c |
HW after, mg | 115.6±11.8 | 76.5±9.4a | 117.7±13.5b | 95.7±12.4a, b, c |
HW/BW ratio | 4.88±0.45 | 3.97±0.33a | 4.92±0.35b | 4.56±0.40a, b, c |
Heart rate, bpm | 548±19 | 542±17 | 567±12 | 554±14 |
IVSd, mm | 0.82±0.08 | 0.72±0.09a | 0.84±0.06b | 0.74±0.07a, c |
LVEDD, mm | 2.69±0.11 | 3.04±0.14a | 2.72±0.08b | 2.83±0.13a, b, c |
LVPWd, mm | 0.87±0.13 | 0.73±0.12a | 0.90±0.13b | 0.77±0.14a, c |
%FS (%) | 54±5 | 38±7a | 55±4b | 51±6a, b, c |
Mean±SD. %FS indicates fractioning shortening; bpm, beats per minute; BW, body weight; Dox, doxorubicin; HW, heart weight; ITCH‐Tg, cardiac‐specific overexpression of ITCH transgenic mouse; IVSd, interventricular septal diameter; LVEDD, left ventricular end‐diastole dimension; LVPWd, left ventricular posterior wall diameter; WT, wild type.
P<0.05 vs WT saline group.
P<0.05 vs WT Dox group.
P<0.05 vs ITCH‐Tg saline group by ANOVA with Scheffe post hoc test.