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. 2015 Dec 31;5(1):e002508. doi: 10.1161/JAHA.115.002508

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© 2015 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley Blackwell.

This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.

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Decreased SHF contribution to Rac1 ^SHF OFT. Fate mapping with mT/mG reporter shows a decreased SHF progenitor contribution to the OFT myocardium (red arrows in B and D) in E12.5 and E14.5 Rac1 ^SHF hearts compared with controls (red arrows in A and C). SHF contribution to the valve leaflets was also severely reduced in Rac1 ^SHF hearts compared with controls (black arrows, A through D). Paraffin sections were immunostained with anti‐GFP. Scale bars: 20 μm. n=3 for each time point per group. Ao indicates aorta; E, embryonic day; OFT, outflow tract; SHF, second heart field.