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. 2016 Jan 25;5(1):e002530. doi: 10.1161/JAHA.115.002530

Figure 1.

Figure 1

Summary of the literature search. Primary analysis studies include data for patients with LVEF ≥50%. Supplemental analysis studies include data either for patients with LVEF ≥40% and/or with preselected echocardiographic indices (eg, the ratio of the early (E) to late (A) ventricular filling velocities (E/A) <0.9). DD/HFpEF represents invasively proven DD/HFpEF (i.e. clinical diagnosis of DD/HFpEF based on clinical sign and symptoms with evidence of elevated LVFP or impaired LV relaxation/chamber stiffness with or without additional biochemical markers and/or other ancillary tests). DD indicates diastolic dysfunction; HF, heart failure; LVEF, left ventricular ejection fraction; LVFP, left ventricular filling pressure; pEF, preserved ejection fraction.