Table 2.

Data for Supplemental Analysis^a

Study (Reference)	LVEF, %	N	Age, y (mean±SD)	Indication for Catheterization	Echo and Catheterization Timing	Correlation to LVFP	2×2 to Predict LVFP	2×2 to Predict DD/HFpEF (Composite Reference Test)b	Specific Reason for Excluding From Primary Analysis	Patient Comorbidities, %
										HF	CAD	HTN	DM
Nagueh et al (1997)13	>50	26	—	Clinically indicated	Simultaneous	—	L (PCWP, from graph)	—	E/A <1	0	—	—	—
Nagueh et al (1998)14	>45	49	—	ICU or cath lab	Simultaneous	L (PCWP)	L (PCWP, from graph)	—	LVEF not ≥50%, sinus tachycardia >100 bpm	—	—	—	—
Poerner et al (2003)17	≥55	85	60±10	Angina/positive exercise test	3±2.5 h	L, S, M (LVEDP, Pre‐A)	—	—	E/A >0.9	—	—	—	—
Arques et al (2005)21	>50	38	76±8	Clinically indicated	Not reported	—	L (HF, limited data)		ASE guidelines cutoff data not available	47	0	100	39
Bruch et al (2005)22	>45	28	68±10	Congestive HF; NYHA 2.4±0.4	≤4 h	M (LVEDP, PCWP)	M (LVEDP, from text)	—	LVEF not ≥50%	100	50	75	—
Hadano et al (2005)23	>50	65	66±9	Clinically indicated	≤3 h	—	L (LVEDP, from graph)	—	Repetitive analysis of same study	—	28	—	—
Weber et al (2006)25	>50	126	59±9	Coronary angiography	Not reported	—	—	S (DD/HF, limited data)	ASE guidelines cutoff data not available	35	49	58	17
Kasner et al (2007)26	>50	55	—	43 exercise dyspnea/12 chest pain	3 to 5 h	—	—	L (HF, limited data)	ASE guidelines cutoff data not available	78	0	62	9
Min et al (2007)27	≥50	55	59±10	Clinically indicated	Simultaneous	S (LVEDP)	S (LVEDP, from graph)	—	8< E/è <15	—	56	46	31
Poerner et al (2007)28	67±10	176	65±10	Coronary angiography	1±2.5 h	—	L (LVEDP, from text/graphs)	—	Assumption: LVEF >40%	—	70	63	25
Dokanish et al (2008)30	>50	32	—	Dyspnea	Sequential	—	M (Pre‐A, limited data)	—	ASE guidelines cutoff data not available	—	—	—	—
Ng et al (2008)31	61±5.6	20	—	Clinically indicated	Sequential	—	M (LVEDP, limited data)	—	AUC ROC only	—	—	—	—
Dokanish et al (2010)34	≥50	122	55±9	Coronary angiography	Sequential	—	M (Pre‐A, from graph)	—	Repetitive analysis of another study22	—	65	88	55
Jaubert et al (2010)36	>45	59	64±12	Clinically indicated	Same morning	—	L (LVEDP, from text)	—	LVEF not ≥50%	—	49	58	36
Kasner et al (2010)37	>60	33	—	21 exercise dyspnea/12 chest pain	Simultaneous	—	—	L (HF, limited data)	AUC ROC only	64	0	61	9
Penicka et al (2010)38	>50	30	67±9	Chronic NYHA II/III dyspnea	Simultaneous	—	L, S, M (LVEDP, from text)	—	Uncertainty with10% patientsc	67	0	70	27
Hsiao et al (2011)40	>50	376	69±13	Coronary angiography, HF survey	Sequential	—	L, S, M (Pre‐A, limited data)	—	ASE guidelines cutoff data not available	—	100	72	47
Kasner et al (2011)41	>50	180	—	107 exercise dyspnea/73 chest pain	Simultaneous	—	—	L (HF, limited data)	AUC ROC only	59	0	43	8
Maeder et al (2011)42	>50	36	56±17	11 PAH/15 HF/10 healthy volunteers and atypical patients	Sequential	—	L, S, M (PCWP, limited data)	—	AUC ROC only	42	—	—	—
Yesildag et al (2011)44	62±7	29	53±10	Clinically indicated	Same day	L, S (LVEDP)	—	—	Assumption: LVEF >40%	—	—	—	—
Hsiao et al (2012)45	>50	376	—	Clinically indicated	Sequential	—	M (Pre‐A, limited data)	—	ASE guidelines cutoff data not available	—	—	—	—
Arques, 201347	≥50	36	66±10	Clinically indicated	Same morning	—	L (LVEDP, from text)	—	ASE guidelines cutoff data not available	—	53	67	42
Manouras et al (2013)48	≥40	65	66±9	Coronary angiography	Simultaneous	L, S, M (LVEDP, Pre‐A)	L, M (LVEDP, Pre‐A, from text)	—	LVEF not ≥50%	—	0	45	42
Weber et al (2013)49	>50	359	64±9	Coronary angiography	Not reported	—	—	S, M (HF, limited data)	AUC ROC only	20	49	83	24

Empty cells are the result of no available data. 2×2 indicates set of true‐positive, false‐positive, false‐negative, and true‐negative values for recommended by American Society of Echocardiography E/è cutoffs; CAD, coronary artery disease; cath lab, catheterization laboratory; CCU, critical care unit; DD, diastolic dysfunction; DM, diabetes mellitus; E/A, the ratio of the early (E) to late (A) ventricular filling velocities; HF, heart failure (clinical diagnosis); HTN, hypertension; ICU, intensive care unit; L, S, and M, lateral, septal, and mean E/è; LVEDP, left ventricular end‐diastolic pressure; LVEF, left ventricular ejection fraction; LVFP, left ventricular filling pressure; LVMDP, left ventricular mean diastolic pressure; N, number of patients; NYHA, New York Heart Association; PAH, pulmonary arterial hypertension; PCWP, pulmonary capillary wedge pressure; pEF, preserved ejection fraction; Pre‐A, left ventricular pre–A wave diastolic pressure; ROC AUC, area under receiver operating characteristic curve.

^aFor supplemental analysis, we included studies that either used a lower LVEF threshold to identify preserved LV systolic function (ie, LVEF ≥40% or 45%) or had no criteria for normal LVEF but the mean and standard deviation for LVEF of the study satisfied the condition that mean minus 2 SDs ≥40%. For a normal distribution, the latter condition assumes that about 98% of participants have LVEF ≥40%. This allowed for inclusion of all clinically relevant studies for secondary analysis since LVEF between 40% to 50% is sometimes used to indicate preserved LVEF.

^bClinical DD/HFpEF was described in studies based on composite of clinical signs and symptoms of HF with invasive parameters of DD with preserved LVEF. Some of these studies also included BNP (brain natriuretic peptide) or NT‐proBNP (N‐terminal of the prohormone brain natriuretic peptide) biochemical levels in composite reference definition. No uniform definition was used for clinical diagnosis of DD/HFpEF across these studies.

^cElevated LVFP group included 3 patients who had LVEDP >16 mm Hg only after hemodynamic interventions.