Table 3.
Models and Adjustments | HR | 95% CI | P Value |
---|---|---|---|
Univariate model | 0.56 | 0.51 to 0.62 | <0.001 |
Multivariate model | |||
Adjusted for diabetes | 0.57 | 0.51 to 0.63 | <0.001 |
Adjusted for ischemic heart disease | 0.56 | 0.51 to 0.62 | <0.001 |
Adjusted for duration of dialysis at enrollment | 0.57 | 0.51 to 0.63 | <0.001 |
Adjusted for No. of hospitalization | 0.55 | 0.50 to 0.61 | <0.001 |
Adjusted for Charlson comorbidity index | 0.56 | 0.51 to 0.62 | <0.001 |
Adjusted for various proceduresa | 0.55 | 0.50 to 0.61 | <0.001 |
Adjusted for medication at enrollmentb | 0.58 | 0.52 to 0.64 | <0.001 |
Final modelc | 0.56 | 0.50 to 0.62 | <0.001 |
Final model adjusted with time‐dependent covariates | |||
Adjusted for the exposure duration of β‐blocker therapy | 0.76 | 0.68 to 0.85 | <0.001 |
Adjusted for the exposure duration of β‐blocker therapy and the exposure duration of ACEI or ARB therapy | 0.80 | 0.72 to 0.90 | <0.001 |
ACEI indicates angiotensin‐converting enzyme inhibitor; ARB, angiotensin receptor blocker; HR, hazard ratio.
The procedures include myocardial perfusion scan, coronary angiography, and percutaneous coronary intervention.
The medications include fibrates, insulins, H2‐antagonists, and proton pump inhibitors.
The control variables include in the final model demographic variables (sex and age), clinically relevant variables (diabetes, ischemic heart disease, duration of dialysis at enrollment, No. of hospitalizations, and Charlson comorbidity index), procedures (myocardial perfusion scan, coronary angiography, and percutaneous coronary intervention), and medications at enrollment (fibrates, insulins, H2‐antagonists, and proton pump inhibitors).