Table 1.

Proteases of chemerin

Proteases	Chemerin Substrate	Chemerin Product	Source	Notes	Model	Ref
Calpains	Prochemerin	Not Determined	Macrophage	Anti-inflammatory	Mouse	18
Carboxy-peptidase B and N		S157		Can be used sequentially with plasmin	Human	19
Cathepsin G	Prochemerin	F148, F156	Neutrophil		Human	15,16
Cathepsin K	Prochemerin	S157, R125		Antibacterial	Human	81
Cathepsin L	Prochemerin	S157, R125		Antibacterial	Human	81
Cathepsin S	Prochemerin	Not Determined	Macrophage	Anti-inflammatory	Mouse	18
Elastase	Prochemerin	S157, A155, G152	Neutrophil		Human	15
Factor XIIa	Prochemerin	Not Determined	Coagulation Cascade		Human	15
Kallikrein 7	Prochemerin	F156		Skin Psoriasis	Human	56
Mast Cell Chymase	S157 and F156	F154	Mast Cell	F154 is inert	Human	20
Plasmin	Prochemerin	K158	Fibrinolytic Cascade		Human	15
Proteinase-3	Prochemerin	A155	Neutrophil	A155 is inert	Human	20
Staphopain B	Prochemerin	S157	S. aureus		Human	82
Tryptase	Prochemerin	K158, A155	Mast Cell		Human	15

Proteases are listed alphabetically with their substrate and product, both of which are named for their C-terminal amino acid (prochemerin in humans has a C-terminus of S¹⁶³, see Table 2a). In cases where the product is not determined, controlled trials revealed that the protease could be fed prochemerin (inert) and turn it into a form that elicits a response by ChemR23.