Table 3.

Effect of hyperthermic (40 – 46°C) temperatures on blood flow

Autor	Tumor	Temperature/conditions	Blood flow/observations
Ardenne and Reitnauer, 1980	DS carcinoma (rats)	Total body heat to 39.5°C plus local heat 43°C/100min	inhibition of tumor microcirculation
		40–41°C
			Tumor pO2 increased
Bicher and Vaupel, 1980	C3H mammary carcinoma, mouse	>41°C
		42.0°C,40min	vascular stasis
Brown et al. 1992	SCC-VII,RIF-1,C3H mammary carcinoma, human mammary carcinomas, mouse	43–46°C/60min	decreased clearance rate, vascular damage followed a 1°C chance eq. change in heating time factor 2
	Muscle tissue, mouse	43–46°C/60min	similar to initial clearance rate
Dickson and carcinomaldenvood, 1980	Yoshida sarcoma, rat	42.0°C/1hr	vascular stasis
Dudar and Jain, 1984	VX2 carcinoma, Rabbit	42.5°C,40min	vascular stasis
		43.0°C/30min	vascular stasis
		43°C2–15min	vaso dilation
Eddy, 1980	Squamous cell carcinoma in hamster cheek pouch	43°C > 15min	mild stasis
		45°C/30min	marked stasis
		40.5°C/40min	no change
	BA1112 rats sarcoma	42.5°C/40min	dilation and congestion
Emami et al, 1981
		44.5°C/40min	hemorrhage and necrosis
	BA-1112 rhabdomyosarcoma, rat	42.5°C/40min	vascular stasis
		40.0°C/1hr	vascular stasis
Endrich et al., 1979	BA-1112 rhabdomyosarcoma, rat		decreased flow and decreased
		41.3°C/1 h
			number of functional capillaries
		>43.0°C/1h	vascular stasis
Gullino et al., 1978	Walker 256 rat mammary carcinoma
		40–42°C/1h	no consistent or predictable change in blood flow or O2 consumption
Rappaport and Song, 1983	13762A carcinoma,rat	43.5°C/1hr	vascular stasis
		42–42.5°C/l h	no change
Reinhold and Van den Berg-Blok,1981	BA-1112 rhabdomyosarcoma, rat	42–42.5°C/2–3h	reduced blood flow and vascular collapse
		42.5°C/2.5hr	vascular stasis
		39°C/45min	unaltered vascular resistance and blood flow
Shrivastav et al. 1983	SMT-2A mammary adenocarcinoma, rat	42°C/45min
			increased blood flow
		45°C/60min
Song at al., 1980b	SCK carcinoma, mouse	40.5°C/30min	vascular stasis
		43°C/1 h	no change in tumor blood flow
Song et al., 1980	Walker 256 carcinoma, rat
		>43.0°C/1hr	vascular stasis
Song et al., 1984	RIF-1 tumor, mouse	42.5°C/1hr	vascular stasis
	SAFA tumor, mouse	42.5°C/1hr
	CAMT, mouse	42.5°C/1hr
Stewart and Begg, 1983			vascular stasis
	CANT, mouse	42.5°C/1hr
	SAF, mouse	42.5°C/1hr
		41/30min	increased blood flow
Sturesson et al., 1999	Rat liver parenchyma
		44°C/30min	decreased blood flow
Sutton,1983	Ependymoblastana, Mouse	42.0°C/1hr	vascular stasis
		42°C/30min	vascular stasis
Vaupel et al., 1980	DA carcinoma in rat kidneys	39.5°C/> 30min	increased blood flow and O2 consumption
		42°C/> 30min	decreased blood flow and O2 consumption
Waterman et al., 1991	Superficial human tumors	40–44°C/60min	blood flow independent of temperature