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. 2015 May 21;1:15010. doi: 10.1038/npjparkd.2015.10

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Copyright © 2015 Parkinson's Disease Foundation/Macmillan Publishers Limited

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Post-treatment with P7C3-S243 protects rats from 6-OHDA-induced motor deficits. (a) Cylinder test showed a significant decrease in the total amount of rearings of 6-OHDA-exposed animals that received vehicle compared with sham-injured animals that received vehicle (**P<0.005; one-way ANOVA), and also to 6-OHDA-exposed animals that were treated with P7C3-S243 (***P<0.001; one-way ANOVA). (n=5 sham—vehicle, n=7 6-OHDA—vehicle, n=16 6-OHDA—P7C3-S243.) (b) Open field test showed a significant decrease in the total distance traveled of 6-OHDA-exposed animals that received vehicle compared with sham-injured animals that received vehicle (***P<0.001; one-way ANOVA), and also with 6-OHDA-exposed animals that were treated with P7C3-S243 (****P<0.0001; one-way ANOVA). (n=7 sham—vehicle, n=17 6-OHDA—vehicle, n=17 6-OHDA—P7C3-S243.) (c) Amphetamine-circling test showed a significant increase in ipsilateral (toward the lesion site) rotations of 6-OHDA-exposed animals that received vehicle compared with sham-injured animals that received vehicle (**P<0.005; one-way ANOVA), and also with 6-OHDA-exposed animals that were treated with P7C3-S243 (***P<0.001; one-way ANOVA). (n=5 sham—vehicle, n=7 6-OHDA—vehicle, n=16 6-OHDA—P7C3-S243.) ANOVA, analysis of variance; 6-OHDA, 6-hydroxydopamine.