Table 3.
Knockout mice models excising that effect the CNS function.
| MODEL NAME | BRAIN/EYE DEFECTS |
|---|---|
| Thrbtm2Df/tm2Df | – Lack of M-opsin expressing cones.106 |
| – S cone gradient in the retina disturbed.106 | |
| TRβ mut | – Impairment in balance and coordination.95 |
| – Reduce cerebellum mass.95 | |
| – Decrease in Purkinje cell layer.95 | |
| Rorasg | – Deficiency of granule cells and Purkinje cells.460 |
| – Cerebellar cortex underdeveloped.460 | |
| Nr4a2tm1Tpe | – Failure to develop dopaminergic neurons.218 |
| Nr2e3rd7/J | – White spots evenly distributed in the retina.461 |
| – Whorls and rossetts can be detected in the retina –Progressive loss of cones and rods.461 | |
| Rorβ−/− | – Loss of rods.167 |
| – Overproduction of primitive S cones.167 | |
| Nr1d1tm1Ven | – Delay cerebellum development.462 |
| – Abnormal Purkinje ad granule cells.462 | |
| RAR β2 γ2−/− | – Marked atrophy and dysplasia of the retina.463 |
| – In the central retina only 2 or 3 rows of nuclei are found.463 | |
| RXRα−/− and RXR β−/− | – Fetus diet at E12.5–16.5.464 |
| – Fetus have conotruncal and ocular defects.464 | |
| – Failure to close the neural tube.464 | |
| TLX KO | – Thickness of the retina is reduces.465 |
| – Increased number of apoptotic cells in the inner nuclear layer of the retina.465 | |
| – Decreased proportion of mitotic cells.465 | |
| Rarbtm2Ipc|Rargtm3Ipc |Tg (Wnt1-cre)11Rth | – Severe ocular abnormalities.213 |
| Rxratm4Ipc|Tg (Tyrp1-cre)1Ipc | – Decreased number of photoreceptors.466 |
| – Abnormal photoreceptor outer segment morphology.466 | |
| – Reduce light response.466 | |
| Nr1h2tm1.1Gstr|Nr1h3tm1.1Gstr | – Abnormal astrocyte morphology.467 |
| – Abnormal brain vasculature morphology.467 |