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. 2016 May 6;12(5):e1005614. doi: 10.1371/journal.ppat.1005614

Fig 4. Analysis of cellular correlates of protection in different immunization groups with and without oral M. avium presensitization.

Fig 4

(A) Experimental design. Arrows indicate M. avium exposure. (B) CD4+ cells, (C) CD8+ cells, (D) CD44hiCD62lo memory cells, (E) CD11b+ (and CD11c+ for lung and BALF) macrophages present in the spleen, lung, and BALF (airway) compartments, n = 8 over 2 separate experiments. A one-way ANOVA Kruskal-Wallis with Dunn’s multiple comparison post-test was used to determine statistical significance. *p < .05; data shown with standard error of the mean (SEM). Abbreviations: Naïve mice with no presensitization or vaccination (No Trt), intradermal BCG only (ID-BCG), oral M. avium presensitization with intradermal BCG vaccination (O-MA + ID-BCG), pulmonary BCG only (Pul-BCG), oral M. avium presensitization with pulmonary BCG vaccination (O-MA + Pul-BCG).