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. 2016 May 6;11(5):e0154933. doi: 10.1371/journal.pone.0154933

Fig 7. Antiproliferative/cytotoxic effect.

Fig 7

B0—original extract, B3—fraction 3 without betulinic acid and lupeol, B4—amorphous fraction of pure betulin, B5—crystalline fraction of pure betulin, B-S—pure betulin obtained from Sigma-Aldrich. The results are given as relative values to the untreated control in percent. Cells treated with topoisomerase II inhibitor doxorubicin at 1 and 2 μM were used as positive control for decreased cell survival. Bars indicate SD in three independent experiments. *Significantly different from control (P ≤ 0.001).