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Model of the CotH-dependent protein interaction network. Shown is a working model of the interactions among the indicated proteins. CotH has a positive effect on the assembly of CotG, CotC, CotU, and CotS (arrows). CotG in turn controls CotB maturation from the immature 46-kDa CotB form to the mature 66-kDa CotB form. The gray line indicates the negative effect of CotG on CotC, CotU, and CotS assembly (17, 20, 30).
