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. 2016 Mar 15;8(3):1339–1354.

Figure 4.

Figure 4

Effect of enalapril, elperenone and combination therapy on glomerular matrix protein accumulation in diabetic db/db mice from weeks 18 to 22. (A) The histological sections stained with PAS and glomerular immunofluorescent staining for fibronectin (FN) and type IV collagen (Col IV) are presented at 400 × magnification. Representative photomicrographs of glomeruli from normal control mice (db/m), diabetic db/db mice without treatment at week 18 (db/db-18 wk) or at week 22 (db/db-22 wk) and diabetic db/db mice treated with enalapril (Ena), eplerenone (Epl), combination of enalapril and eplerenone (Ena+Epl). Graphic representations of glomerular matrix score (B), FN staining score (C) and Col IV staining score (D) are shown below. *P<0.05, vs. db/m. #P<0.05, vs. db/db-18 wk. §P<0.05, vs. db/db-22 wk. ‡P<0.05, vs. db/db+Ena. ζP<0.05, vs. db/db+Epl.