Table 2.

Associations of SIAH2 protein levels with clinicopathological factors of 746 patients from the primary breast cancer (PBC) cohort

Characteristic	N	%	Low SIAH2 protein expression*	%	High SIAH2 protein expression**	%	P-valueα
All patients	746	100	483	65	263	35
Age (years)
≤ 40	73	10	36	7	37	14	0.001β
41-55	309	41	192	40	117	44
56-70	249	33	167	35	82	31
> 70	115	15	88	18	27	10
Menopausal status
Premenopausal	347	47	205	42	142	54	0.003
Postmenopausal	399	53	278	58	121	46
Tumor stage
pT1	426	57	299	62	127	48	0.001
pT2/9	279	37	158	33	121	46
pT3/4	41	5	26	5	15	6
Lymph nodes involved
0	410	55	259	54	151	57	0.132
1-3	217	29	152	31	65	25
> 3	119	16	72	15	47	18
Differentiation grade#
1	142	19	135	28	7	3	< 0.001
2	334	45	248	51	86	33
3	270	36	100	21	170	65
Tumor histology
IDC	653	88	426	88	227	86	0.055
ILC	28	4	22	5	6	2
other	65	9	36	7	30	11
ER status†
Negative	136	18	45	9	91	35	< 0.001
Positive	610	82	438	91	172	65
PgR status†
Negative	275	37	129	27	146	56	< 0.001
Positive	471	63	354	73	117	44
HER2/neu status†
Negative	657	88	441	91	216	82	< 0.001
Positive	89	12	42	9	47	18
EGFR expression†
Negative	692	93	458	95	234	89	0.003
Positive	54	7	25	5	29	11
CK5 expression†
Negative	577	77	413	86	164	62	< 0.001
Positive	169	23	70	14	99	38

Abbreviations: IDC, invasive ductal carcinoma; ILC, invasive lobular carcinoma; ER, estrogen receptor; PgR, progesterone receptor; EGFR, epidermal growth factor receptor; CK5, cytokeratin 5.

^*SIAH2 negative defined as ≤ 20% cells positive for SIAH2 staining.

^**SIAH2 positive defined as > 20% cells positive for SIAH2 staining.

^α P for Pearson’s Chi-squared test;

^βMann-Whitney U test.

^#According to the Bloom-Richardson score.

^†As retrieved from TMA.