Table 4.

Cox univariate and multivariate analysis for metastasis-free survival of SIAH2 protein expression levels. Analysis was performed in all 746 patients from the PBC-cohort

			Univariate analysis			Multivariate analysis
Factor of base model	N	%	HR	95% CI	P-value	HR	95% CI	P-value
All patients	746	100
Age (years)
≤ 40	73	10	1.00			1.00
41-55	309	41	0.66	0.46 to 0.95	0.027	0.80	0.55 to 1.16	0.243
56-70	249	33	0.58	0.40 to 0.86	0.006	0.91	0.48 to 1.71	0.767
> 70	115	15	0.57	0.36 to 0.92	0.023	0.86	0.42 to 1.75	0.673
Menopausal status
Premenopausal	347	47	1.00			1.00
Postmenopausal	399	53	0.79	0.62 to 1.01	0.057	0.82	0.49 to 1.37	0.452
Tumor stage
pT1	426	57	1.00			1.00
pT2/9	279	37	1.85	1.44 to 2.37	< 0.001	1.50	1.15 to 1.94	0.002
pT3/4	41	5	2.75	1.76 to 4.30	< 0.001	1.89	1.19 to 3.00	0.007
Lymph nodes involved
0	410	55	1.00			1.00
1-3	217	29	1.61	1.22 to 2.13	0.001	1.49	1.12 to 1.97	0.006
> 3	119	16	2.92	2.16 to 3.93	< 0.001	1.76	1.76 to 3.31	< 0.001
Differentiation grade
1	85	25	1.00			1.00
2	164	49	2.44	1.30 to 4.59	0.006	2.30	1.21 to 4.34	0.011
3	87	26	3.24	1.67 to 6.30	0.001	3.14	1.58 to 6.27	0.001
ER status†
Negative	136	18	1.00			1.00
Positive	610	82	0.79	0.59 to 1.07	0.124	0.95	0.64 to 1.41	0.800
PgR status†
Negative	275	37	1.00			1.00
Positive	471	63	0.91	0.71 to 1.16	0.429	1.18	0.85 to 1.64	0.316
HER2 status†
Negative	657	88	1.00			1.00
Positive	89	12	1.39	0.99 to 1.95	0.056	1.25	0.88 to 1.78	0.208
SIAH2 protein expression						Added to the base model
Low (≤ 20% positive cells)	483	65	1.00			1.00
High (> 20% positive cells)	263	35	1.41	1.11 to 1.80	0.005	1.09	0.82 to 1.43	0.565

Abbreviations: HR, hazard ratio; ER, estrogen receptor; PgR, progesterone receptor.

^†As retrieved from TMA.