Table 5.

Cox univariate and multivariate analysis for progression-free survival of SIAH2 protein expression levels. Analysis was performed in 610 patients with ER-positive breast cancer from the PBC-cohort

			Univariate analysis			Multivariate analysis
Factor of base model	N	%	HR	95% CI	P-value	HR	95% CI	P-value
All patients	610	100
Age (years)
≤ 40	53	9	1.00			1.00
41-55	250	41	0.64	0.42 to 0.97	0.034	0.74	0.48 to 1.13	0.165
56-70	208	34	0.54	0.35 to 0.83	0.006	0.64	0.31 to 1.31	0.221
> 70	99	16	0.57	0.33 to 0.97	0.037	0.67	0.30 to 1.49	0.330
Menopausal status
Premenopausal	280	46	1.00			1.00
Postmenopausal	330	54	0.83	0.63 to 1.08	0.159	1.04	0.58 to 1.86	0.898
Tumor stage
pT1	361	59	1.00			1.00
pT2/9	221	36	1.88	1.43 to 2.48	< 0.001	1.51	1.13 to 2.01	0.005
pT3/4	28	5	2.50	1.45 to 4.29	0.001	1.81	1.04 to 3.18	0.037
Lymph nodes involved
0	336	55	1.00			1.00
1-3	180	30	1.52	1.12 to 2.08	0.008	1.37	1.00 to 1.88	0.048
> 3	94	15	2.77	1.98 to 3.87	< 0.001	2.30	1.61 to 3.29	< 0.001
Differentiation grade
1	138	23	1.00			1.00
2	307	50	2.04	1.36 to 3.07	0.001	1.70	1.12 to 2.57	0.013
3	165	27	2.86	1.76 to 4.39	< 0.001	2.47	1.58 to 3.86	< 0.001
PgR status†
Negative	146	24	1.00			1.00
Positive	464	76	0.94	0.69 to 1.28	0.690	1.11	0.79 to 1.54	0.552
HER2 status†
Negative	553	91	1.00			1.00
Positive	57	9	1.53	1.02 to 2.31	0.041	1.25	0.81 to 1.92	0.318
SIAH2 protein expression						Added to the base model
Low (≤ 20% positive cells)	438	72	1.00			1.00
High (> 20% positive cells)	172	28	1.42	1.07 to 1.89	0.014	1.00	0.72 to 1.37	0.977

Abbreviations: HR, hazard ratio; PgR, progesterone receptor.

^†As retrieved from TMA.