Skip to main content
. 2016 Jan 15;6(2):312–320.

Figure 4.

Figure 4

miR-34a/LDHA axis promotes tumor progression of cervical cancer. (A) The protein level of LDHA in LDHA siRNA-treated HeLa and SiHa cells was detected by quantitative real-time PCR. (B) Colony formation ability of HeLa and SiHa cells was also significantly reduced upon LDHA knockdown; si-Ctrl versus si-1 or si-2, *P < 0.05, **P < 0.01. (C) Knockdown of LDHA inhibited cell invasive capacity as revealed by Matrigel invasion chamber; si-Ctrl versus si-1 or si-2, *P < 0.05, **P < 0.01. (D) Representative immunoblots of LDHA protein upon introduction of miR-34a or overexpression of LDHA. Ectopic expression of miR-34a inhibited colony formation ability (E) and cell invasive capacity (F) in HeLa and SiHa cells, and restoration of LDHA completely abolished miR-34a-mediated effects; *P < 0.05, **P < 0.01.