Table 3.
Chemosensitizing effects of BR/NAC pretreatment on LS174T cells
| SE4 h | |||||
|
|
|||||
| BR 10 | SENS | p values | BR 20 | SENS | p values |
|
| |||||
| CTL | NA | n | CTL | NA | n |
| Cis 10 | + | 0.0017 | Cis 10 | + | 0.0012 |
| Cis 20 | - | n | Cis 20 | - | n |
| 5FU 10 | + | n | 5FU 10 | + | n |
| 5FU 50 | + | n | 5FU 50 | + | 0.0037 |
| PTX 10 | + | 0.0211 | PTX 10 | + | 0.0376 |
| PTX 50 | - | n | PTX 50 | + | n |
| VCR 10 | - | n | VCR 10 | + | n |
| VCR 50 | - | 0.0001 | VCR 50 | - | 0.0006 |
|
| |||||
| BR 30 | BR 10/NAC 20 | ||||
| CTL | NA | n | CTL | NA | n |
| Cis 10 | + | 0.0038 | Cis 10 | + | 0.0098 |
| Cis 20 | + | n | Cis 20 | - | < 0.0001 |
| 5FU 10 | + | n | 5FU 10 | + | 0.0027 |
| 5FU 50 | + | 0.0019 | 5FU 50 | + | < 0.0001 |
| PTX 10 | + | < 0.0001 | PTX 10 | + | 0.0002 |
| PTX 50 | + | n | PTX 50 | + | n |
| VCR 10 | - | n | VCR 10 | + | n |
| VCR 50 | - | 0.0085 | VCR 50 | - | 0.0010 |
|
| |||||
| BR 20/NAC 10 | |||||
| CTL | NA | n | |||
| Cis 10 | + | 0.0004 | |||
| Cis 20 | - | n | |||
| 5FU 10 | + | 0.0008 | |||
| 5FU 50 | + | < 0.0001 | |||
| PTX 10 | + | < 0.0001 | |||
| PTX 50 | - | n | |||
| VCR 10 | + | n | |||
| VCR 50 | - | 0.0037 | |||
SENS: Sensitization, NA: not applicable; +: chemosensitized (better response compared to “no pretreatment” control); CTL: pretreatment-only control; Cis: cisplatin; 5FU: 5-fluorouracil; PTX: paclitaxel; VCR: vincristine; n: not significant. Significant results (p < 0.05) are shown in bold.