Table 3.

OS methylation rate of change and cancer incidence

	Cancer-free	All-cancer	p
CRAT
N	291	56
Mean (units/year)	-0.007	0.06	0.035*
HR (95% CI)	REF	3.88 (1.06-14.3)	0.041*
INOS
N	222	39
Mean (units/year)	0.017	-0.10	0.0037*
HR(95% CI)	REF	0.08 (0.02-0.38)	0.001*
OGG1
N	192	38
Mean (units/year)	-0.03	-0.05	0.77
HR(95% CI)	REF	0.64 (0.11-3.75)	0.62
GCR
N	269	55
Mean (units/year)	-0.02	0.01	0.52
HR (95% CI)	REF	1.51 (0.47-4.87)	0.49

^*Statistically significant at p<0.05.