TABLE 1.

Human leukocyte reconstitution in the peripheral blood of NSG mice transduced with AAV9-DR1/DR4, AAV9-human BAFF, and AAV9-human cytokines^a

HIS mouse identifier	% cells
	Human PBMCs	CD3 human T cells	CD8 human T cells	CD4 human T cells	CD19 human B cells	CD161+ CD3− human NK cells
57b	94.5	18.5	22.8	73.6	48	25.8
61b	86.6	29.4	30.2	67.3	49.1	11.7
584b	70	75.4	35.6	63.9	15	6.5
336b	86.7	74.3	50	49.3	15.9	5
585b	83.8	61.9	37	62.2	22.3	8.8
600b	78.7	90.7	33.2	66.5	1	3.4
302b	85.8	74	18.7	80.9	19.1	2.5
330b	64.2	54.3	15.8	83.4	32.6	5.6
700b	58.9	52	21.6	78.3	38.5	3.4
830	81.5	20.2	29.7	50.2	49	19.2
837	87.9	7.3	3.1	7.9	49.8	16.4
842	32.5	30.9	36.5	45.6	28.6	6
846	65.9	30.9	42.5	50.9	49.8	13.2
847	3.1	6.4	20	80	7.7	7.7
849	11.8	69	52.3	45	4.4	2.5
141	18.9	4.5	33.3	43.3	35.5	4.6
145	8.2	17.1	55.9	26.5	25.1	9
831	59	19.1	21.8	30	47.9	13.4
845	12.6	4.1	23.5	41.2	56.4	20.2
668	80.4	87	26.2	72.1	1.3	8.9
669	79	74.9	48.5	48.8	2	18.1
672	81.6	67.3	42.3	56.4	5.4	20.9
682	98	68.9	42	56.9	10.1	17.5
628	44.7	31.6	26.3	71.3	1.4	55.9
629	83.1	0.3	58.8	0	1.7	83.5
681	10.1	0	0	0	8.8	33.3

^aThe level of human CD45⁺ cell reconstitution in the blood was determined using flow cytometry at 15 weeks after human CD34⁺ cells were engrafted into NSG mice transduced with an AAV9 vector carrying HLA-DR1/DR4, human BAFF, or selected human cytokines. Shown are the percentages of human CD3⁺ T cells, human CD4⁺ T cells, and CD19⁺ B cells within human CD45⁺ cells in the blood of various HIS mice.

^bHIS mice utilized to study short-term responses to RSV infection.