FIG 7.
Effects of p7 inhibitors on infectivity of HCV/NPHV p7 chimeras. In vitro transcripts of Jc1, Jc1 p7J6-loop-H14, and Jc1 p7J6-C-ter-H14 were electroporated into Huh-7.5 cells. Four hours posttransfection, the respective drug in two different concentrations or DMSO was added. The percentage of infectivity was calculated by determining the viral titer by TCID50 and normalizing to the DMSO control. Three independent experiments were performed. Test results of the inhibitory effect of rimantadine (50 μM, 100 μM) (A), NN-DGJ (5 μM, 50 μM) (B), and NN-DNJ (5 μM, 50 μM) (C).