FIG 1.
Inhibition of HIV-1JR-FL infection by CD4-mimetic compounds. Recombinant HIV-1 encoding firefly luciferase was pseudotyped with the HIV-1JR-FL Env or the A-MLV Env. Viruses were incubated with Cf2Th-CD4/CCR5 cells in the presence of the indicated concentrations of the CD4-mimetic compounds BNM-III-170 and BNM-IV-147. After 48 h, the luciferase activity in the target cells was measured. The level of infection relative to that seen in the absence of the compound is reported. The means and standard deviations from triplicate samples within a typical experiment are shown.