FIG 1.

Combined i.n./i.m. HIV-1 Env vaccine regimen. Lactation was hormonally induced in four female rhesus macaques prior to weeks 0, 12, and 50 so that milk samples could be collected at each time point. Animals were primed with recombinant MVA expressing HIV Env C.1086 gp140 and then boosted twice with HIV Env C.1086 gp120 i.n. with R848 adjuvant. The animals were then boosted a third time using a combined i.n./i.m. Env boost with C.1086 gp120 i.n. plus R848 adjuvant as well as C.1086 gp120 i.m. plus STR8S-C adjuvant.