FIG 4.
Changes in miRNA expression in intestinal LPLs of rhesus macaques at 180 days post-SIV infection compared to the preinfection time point. (A) Heat map shows all differentially expressed (P < 0.05) miRNAs in intestinal LPLs of rhesus macaques at 180 dpi. (B) Table shows raw CT, fold change, and P values for all differentially expressed miRNAs in LPLs at 180 dpi. miRNA species originating from the opposite arm of the precursor are denoted with an asterisk. (C) qRT-PCR confirmation of select differentially expressed miRNAs at 180 dpi (n = 6) relative to preinfection samples (n = 5). Data were analyzed using the nonparametric Wilcoxon's rank-sum test for independent samples. The error bars represent standard errors of means of fold changes within each group. A single asterisk indicates statistical significance (P < 0.05) compared to preinfection controls.