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. Author manuscript; available in PMC: 2016 May 6.
Published in final edited form as: Entropy (Basel). 2015 Jul 27;17(8):5288–5303. doi: 10.3390/e17085288

Figure 1.

Figure 1

Dose-toxicity relationship for P(DLT|dose) on the left hand side and for P(grade 2 or higher|dose) on the right hand side, for three selected values of true MTD, for five models considered in the simulation studies: proportional odds logistic (black), normal with σ = 0.5 (red), normal with σ = 2 (green), non-proportional odds with ρ0 = 0.126 (blue), and non-proportional odds with ρ0 = 0.02 (magenta). The horizontal dashed lines represent the target probability of DLT θ = 0.33 and the vertical lines correspond to the true values of the MTDγ.