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. Author manuscript; available in PMC: 2016 May 6.
Published in final edited form as: Ann Appl Stat. 2016 Mar;10(1):286–304. doi: 10.1214/15-AOAS891

Table 3.

Mean bias (%) in the ΔAUC and IDI under marker-dependent outcome misclassification (π = 0.3)

Misclassification rate among events
0.05
 0.1
 0.2
 0.4
γ 1 a γ 2 a ΔAUC IDI ΔAUC IDI ΔAUC IDI ΔAUC IDI
−0.5 −0.5 −1.1 0.4 −3.4 −0.1 −5.2 0.2 −6.8 4.2
−0.5 0 −5.6 −2.4 −11.7 −5.9 −21.0 −10.4 −37.6 −17.6
−0.5 0.5 −9.1 −4.9 −20.6 −12.5 −31.6 −19.7 −66.1 −39.0
0 −0.5 1.7 0.8 2.3 1.1 5.9 1.9 16.0 7.6
0 0 −1.9 −1.8 −6.3 −4.6 −9.5 −8.3 −17.4 −17.1
0 0.5 −4.7 −4.1 −12.5 −11.4 −19.7 −18.0 −39.5 −34.1
0.5 −0.5 5.1 1.7 6.5 1.6 15.9 3.9 30.3 8.3
0.5 0 1.3 −1.0 1.1 −3.5 5.2 −4.9 14.7 −5.6
0.5 0.5 −0.6 −3.0 −4.5 −9.4 −6.9 −14.7 −11.3 −27.2
a

γ1 and γ2 correspond to the associations between markers X and Z, respectively, and the log odds of misclassification among events.