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The effects of UCP1 and UCP2 on glycolysis. (a, b) MnSOD-knockdown human keratinocyte HaCaT cells (shMnSOD) were transfected with siRNA to silence either UCP1 or UCP2 and alterations in OCR and ECAR were quantified. (c) ATP production was analyzed. (d) Cellular lactate concentration was measured. (e) Corresponding proteins levels were confirmed.
