Figure 2.

Auditory Electrophysiology and Whrn Expression in Whrn^wi/wi and Whrn^tm1b/tm1b Mice

(A) Mean CAP threshold (±SD) in P20 Whrn^wi mice.

(B) Mean ABR threshold (±SD) in P20 Whrn^wi mice.

(C) Mean ABR threshold (±SD) in P98 Whrn^wi mice.

(D) Mean ABR threshold (±SD) in P98 Whrn^tm1b mice.

(E) Mean ABR masked tuning curves (±SD) in P98 Whrn^tm1b mice. Open symbols indicate mean (±SD) 12 kHz probe tone threshold. Filled symbols indicate mean (±SD) masked tuning thresholds.

(F) Mean 2F1-F2 DPOAE threshold (±SD) in P98 Whrn^tm1b mice. Red arrows on symbols indicate maximum sound pressure level tested.

(G) Waveforms from Whrn^+/wi mouse (P17) showing range of responses. CAP and SP responses are indicated. SP can be either negative (e.g., 12 kHz at 70 dB SPL) or positive (high frequencies, high intensities).

(H) Waveforms from a Whrn^wi/wi mutant (P17), showing positive and negative SPs but no CAP.

(I) Cochlear microphonic amplitudes plotted as a function of stimulus intensity for a 6 kHz tone.

(J) LacZ staining in organ of Corti from Whrn^tm1b/tm1b mice at P5 (left: whole cochlea, right top: magnified) and P28 (bottom right).

See also Figure S2.