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. 2016 Mar 16;263:927–936. doi: 10.1007/s00415-016-8051-1

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© The Author(s) 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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Fig. 2 — Progression of Cho/NAA ratios over time. Zero time point represents the start of follow-up period; thick coloured lines represent average prediction based on linear mixed modelling analysis, and thinner grey lines represent individual patient profiles. Dashed horizontal line represents normal values based on values from healthy controls (Personal Communication, D Galanaud, 2014)